Sharma Lab focuses on the triquetra of early development, regeneration, and cancer. We are interested in understanding the developmental origin of cancer by uncovering the similarities between embryogenesis and tumor development. In close association with our clinical collaborators, we study how tumors co-evolve with their microenvironment, especially in the context of tumor initiation and drug-resistance. To address these questions, we combine single-cell genomics, spatial transcriptomics, and machine learning approaches. We are expanding our collaborations to integrate experimental, computational, and clinical knowledge to exhume the ‘seeds’ of cancer development.